Invention Grant
- Patent Title: Quinolinone derivatives as PARP inhibitors
- Patent Title (中): 喹啉酮衍生物作为PARP抑制剂
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Application No.: US12681790Application Date: 2008-10-22
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Publication No.: US08404713B2Publication Date: 2013-03-26
- Inventor: Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Jorge Eduardo Vialard , Laurence Anne Mevellec , Christophe Meyer , Pierre-Henri Storck
- Applicant: Patrick René Angibaud , Laurence Françoise Bernadette Marconnet-Decrane , Jorge Eduardo Vialard , Laurence Anne Mevellec , Christophe Meyer , Pierre-Henri Storck
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP07119417 20071026
- International Application: PCT/EP2008/064243 WO 20081022
- International Announcement: WO2009/053373 WO 20090430
- Main IPC: A61K31/04
- IPC: A61K31/04 ; C07D215/38
Abstract:
Compounds of formula (I): wherein R1, R2, R3, R4, R5, Z and n have defined meanings, the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary ammonium salts and the stereochemically isomeric forms thereof, and their use for the treatment of PARP-mediated disorders.
Public/Granted literature
- US20100222348A1 QUINOLINONE DERIVATIVES AS PARP INHIBITORS Public/Granted day:2010-09-02
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