Invention Grant
- Patent Title: Storage-stable formulation of paracetamol in aqueous solution
- Patent Title (中): 扑热息痛在水溶液中的储存稳定配方
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Application No.: US12797478Application Date: 2010-06-09
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Publication No.: US08404748B2Publication Date: 2013-03-26
- Inventor: Khaled Al Dandachi Atassi
- Applicant: Khaled Al Dandachi Atassi
- Applicant Address: BE Diegem
- Assignee: Neogen N.V.
- Current Assignee: Neogen N.V.
- Current Assignee Address: BE Diegem
- Agency: Knobbe, Martens, Olson & Bear LLP
- Main IPC: A61K31/67
- IPC: A61K31/67 ; A61P29/00

Abstract:
The present invention concerns a liquid formulation that is stable to oxidation and that is based on paracetamol in an aqueous solvent obtainable by the following steps: (i) dissolving in a reaction vessel paracetamol in an aqueous solvent having a temperature between 65° C. and 95° C., and having pH between 5.0 and 6.0; (ii) cooling the solution so formed to a temperature equal to or above 35° C. and below 40° C. under an atmosphere of nitrogen; (iii) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring; (iv) closing the reaction vessel, and stirring the solution of step iii) in a nitrogen atmosphere. It further relates to a method for preparing the formulation.
Public/Granted literature
- US20110039938A1 STORAGE-STABLE FORMULATION OF PARACETAMOL IN AQUEOUS SOLUTION Public/Granted day:2011-02-17
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