Invention Grant
- Patent Title: Method for generating aptamers with improved off-rates
- Patent Title (中): 用于产生具有改善的脱离率的适配体的方法
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Application No.: US12969239Application Date: 2010-12-15
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Publication No.: US08404830B2Publication Date: 2013-03-26
- Inventor: Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
- Applicant: Dominic Zichi , Sheri K. Wilcox , Chris Bock , Daniel J. Schneider , Bruce Eaton , Larry Gold
- Applicant Address: US CO Boulder
- Assignee: SomaLogic, Inc.
- Current Assignee: SomaLogic, Inc.
- Current Assignee Address: US CO Boulder
- Agency: Swanson & Bratschun, L.L.C.
- Main IPC: C07H19/00
- IPC: C07H19/00 ; C07H21/04
Abstract:
The present disclosure is directed to the field of nucleic acid chemistry, specifically to 5-position modified uridines, as well as, oligonucleotides comprising said 5-position modified uridines. The present disclosure describes methods for producing aptamers comprising said 5-position modified uridines that are capable of binding to target molecules.
Public/Granted literature
- US20110082286A1 Method for Generating Aptamers with Improved Off-Rates Public/Granted day:2011-04-07
Information query
