Invention Grant
- Patent Title: Method for producing diamine derivative
- Patent Title (中): 二胺衍生物的制备方法
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Application No.: US13162922Application Date: 2011-06-17
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Publication No.: US08404847B2Publication Date: 2013-03-26
- Inventor: Takeo Koyama
- Applicant: Takeo Koyama
- Applicant Address: JP Tokyo
- Assignee: Daiichi Sankyo Company, Limited
- Current Assignee: Daiichi Sankyo Company, Limited
- Current Assignee Address: JP Tokyo
- Agency: Locke Lord LLP
- Priority: JP2008-320693 20081217
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D513/02

Abstract:
The present invention provides a method for producing a compound represented by formula (A), the method comprising the steps of: (a) mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate at less than 1 molar equivalent with respect to the compound represented by formula (B) in a solvent under heating; (b) adding additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the mixed solution under cooling, wherein the additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate is added in such an amount that the total molar equivalent thereof with the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate of step (a) is 1 molar equivalent or more with respect to the compound represented by formula (B) of step (a); and (c) subsequently allowing the mixed solution to crystallize to obtain the compound represented by formula (A).
Public/Granted literature
- US20110275821A1 METHOD FOR PRODUCING DIAMINE DERIVATIVE Public/Granted day:2011-11-10
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