Invention Grant
US08404874B2 (20R,25S)-2-Methylene-19,26-Dinor-1α,25-Dihydroxyvitamin D3 in crystalline form
有权
（20R，25S）-2-亚甲基-19,26-二烯-1α，结晶形式的25-二羟基维生素D3
- Patent Title: (20R,25S)-2-Methylene-19,26-Dinor-1α,25-Dihydroxyvitamin D3 in crystalline form
- Patent Title (中): （20R，25S）-2-亚甲基-19,26-二烯-1α，结晶形式的25-二羟基维生素D3
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Application No.: US13247600Application Date: 2011-09-28
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Publication No.: US08404874B2Publication Date: 2013-03-26
- Inventor: Hector F. DeLuca , Pawel Grzywacz , James B. Thoden , Hazel Holden
- Applicant: Hector F. DeLuca , Pawel Grzywacz , James B. Thoden , Hazel Holden
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Andrus, Sceales, Starke & Sawall, LLP
- Main IPC: C07C401/00
- IPC: C07C401/00 ; A61K31/59
Abstract:
A method of purifying (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 to obtain (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 in crystalline form. The method includes the steps of preparing a solvent of methanol and water, dissolving a product containing (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 crystals, and recovering the (20R,25S)-2-methylene-19,26-dinor-1α,25-dihydroxyvitamin D3 crystals.
Public/Granted literature
- US20120083614A1 (20R,25S)-2-Methylene-19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 in Crystalline Form Public/Granted day:2012-04-05
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