A folded cascode differential amplifier includes a high-voltage input stage and a low-voltage output stage. The input stage is formed from high-voltage MOS transistors, two of which constitute a differential pair. The output stage is formed from low-voltage MOS transistors, some of which constitute a current mirror circuit connected to the differential pair. The output stage also includes at least one transistor that amplifies a voltage produced in the current mirror circuit to generate an output voltage signal. The high-voltage MOS transistors have higher breakdown voltages than the low-voltage MOS transistors. Incorporation of both types of transistors into a single amplifier reduces the necessary number of transistors and the necessary number of bias voltages.