A method, a system and a computer program product for reducing coupling noise in low loss on-module wires used for connecting module components in electrical circuits/devices. During the design stage, an Enhanced Crosstalk Reduction (ECR) utility identifies interconnect wires as driven/aggressor traces or receiver traces. The ECR utility substantially avoids forward crosstalk in a victim trace by specially arranging driver traces adjacent to the receiver victim trace in order to provide a lower level and saturated level of backward crosstalk. In particular, the ECR utility provided a configuration of wire/trace layers based on one or more of: (a) the crosstalk impact of a trace when positioned in a particular location; (b) the crosstalk impact of the trace upon remaining components based on placement in the particular location; and (c) system component specifications. In addition, the ECR utility reduces crosstalk by providing a configuration of receiver wires and transmitter wires without the use of isolation layers.