A method of and apparatus for searching for a signature in a packet according to a signature location. The method may include extracting a sub-payload to be compared with a signature from a payload of a packet, generating an offset that is location information about a location of the sub-payload in the payload, generating a search key that includes the extracted sub-payload and the generated offset, and performing ternary content addressable memory (TCAM) matching to check if the generated search key matches a TCAM entry.