Invention Grant
- Patent Title: Monoclonal antibodies with enhanced ADCC function
- Patent Title (中): 具有增强ADCC功能的单克隆抗体
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Application No.: US13436114Application Date: 2012-03-30
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Publication No.: US08409572B2Publication Date: 2013-04-02
- Inventor: Roland Beliard , Dominique Bourel , Arnaud Glacet , Christophe De Romeuf , Nicolas Bihoreau , Emmanuel Nony
- Applicant: Roland Beliard , Dominique Bourel , Arnaud Glacet , Christophe De Romeuf , Nicolas Bihoreau , Emmanuel Nony
- Applicant Address: FR les Ulis
- Assignee: Laboratoire Francais du Fractionnement et des Biotechnologies
- Current Assignee: Laboratoire Francais du Fractionnement et des Biotechnologies
- Current Assignee Address: FR les Ulis
- Agency: Foley & Lardner LLP
- Priority: FR0004685 20000412
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/00 ; C12P21/08 ; C07K1/00
Abstract:
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fcy receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunization in Rh negative persons, in particular for haemolytic disease in a new-born baby of for uses such as idiopathic thrombocytopenic purpura (ITP).
Public/Granted literature
- US20120259095A1 MONOCLONAL ANTIBODIES WITH ENHANCED ADCC FUNCTION Public/Granted day:2012-10-11
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