Invention Grant
- Patent Title: Methods for treating pain by inhibition of the SCN9A channel
- Patent Title (中): 通过抑制SCN9A通道治疗疼痛的方法
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Application No.: US12590935Application Date: 2009-11-17
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Publication No.: US08410054B2Publication Date: 2013-04-02
- Inventor: Marcia L. MacDonald , Mark E. Samuels , Robin Sherrington , Yigal P. Goldberg
- Applicant: Marcia L. MacDonald , Mark E. Samuels , Robin Sherrington , Yigal P. Goldberg
- Applicant Address: CA Burnaby, B.C.
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby, B.C.
- Agent Elliot M. Olstein; Alan J. Grant
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/16
Abstract:
The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.
Public/Granted literature
- US20100076058A1 Methods for identifying analgesic agents Public/Granted day:2010-03-25
Information query
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