Invention Grant
US08410066B2 Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
有权
E-选择蛋白和CXCR4趋化因子受体的异双功能抑制剂
- Patent Title: Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
- Patent Title (中): E-选择蛋白和CXCR4趋化因子受体的异双功能抑制剂
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Application No.: US12768173Application Date: 2010-04-27
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Publication No.: US08410066B2Publication Date: 2013-04-02
- Inventor: John L. Magnani , Arun K. Sarkar
- Applicant: John L. Magnani , Arun K. Sarkar
- Applicant Address: US MD Gaithersburg
- Assignee: GlycoMimetics, Inc.
- Current Assignee: GlycoMimetics, Inc.
- Current Assignee Address: US MD Gaithersburg
- Agency: Seed IP Law Group PLLC
- Main IPC: A61K31/7036
- IPC: A61K31/7036 ; C07H17/02 ; C07H15/207 ; C07H3/06
Abstract:
Compounds, compositions and methods are provided for treating cancer and inflammatory diseases, and for releasing cells such as stem cells (e.g., bone marrow progenitor cells) into circulating blood and enhancing retention of the cells in the blood. More specifically, heterobifunctional compounds that inhibit both E-selectins and CXCR4 chemokine receptors are described.
Public/Granted literature
- US20100279965A1 HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTINS AND CXCR4 CHEMOKINE RECEPTORS Public/Granted day:2010-11-04
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