Invention Grant
US08410070B2 Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
有权
用于治疗癌症，抑制增殖和诱导细胞死亡的组合物和方法
- Patent Title: Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
- Patent Title (中): 用于治疗癌症，抑制增殖和诱导细胞死亡的组合物和方法
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Application No.: US13063509Application Date: 2009-09-11
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Publication No.: US08410070B2Publication Date: 2013-04-02
- Inventor: Donald M. Miller , Shelia Diann Thomas , Kara Joyce Sedoris
- Applicant: Donald M. Miller , Shelia Diann Thomas , Kara Joyce Sedoris
- Applicant Address: US KY Louisville
- Assignee: University of Louisville Research Foundation, Inc.
- Current Assignee: University of Louisville Research Foundation, Inc.
- Current Assignee Address: US KY Louisville
- Agency: Dinsmore & Shohl LLP
- International Application: PCT/US2009/056615 WO 20090911
- International Announcement: WO2010/030849 WO 20100318
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K48/00 ; C07H21/02 ; C07H21/04
Abstract:
Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a patient are provided, including (i) a safe and effective amount of a sequence having at least 80% nucleic acid identity with a guanine-rich promoter gene oligonucleotide (GPGO), and (ii) a carrier, wherein the oligonucleotide forms at least one quadruplex.
Public/Granted literature
- US20110213019A1 Compositions and Methods for Treating Cancer, Inhibiting Proliferation, and Inducing Cell Death Public/Granted day:2011-09-01
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