Invention Grant
US08410083B2 23-substituted bile acids as TGR5 modulators and methods of use thereof
有权
23-取代胆汁酸作为TGR5调节剂及其使用方法
- Patent Title: 23-substituted bile acids as TGR5 modulators and methods of use thereof
- Patent Title (中): 23-取代胆汁酸作为TGR5调节剂及其使用方法
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Application No.: US12523670Application Date: 2008-01-18
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Publication No.: US08410083B2Publication Date: 2013-04-02
- Inventor: Roberto Pellicciari
- Applicant: Roberto Pellicciari
- Applicant Address: US NY New York
- Assignee: Intercept Pharmaceuticals, Inc.
- Current Assignee: Intercept Pharmaceuticals, Inc.
- Current Assignee Address: US NY New York
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Ivor R. Elrifi; Jennifer L. Loebach
- Priority: EP07001143 20070119; EP07012079 20070620
- International Application: PCT/US2008/000658 WO 20080118
- International Announcement: WO2008/091540 WO 20080731
- Main IPC: A61K31/575
- IPC: A61K31/575 ; A61K31/56 ; C07J9/00
Abstract:
The invention relates to compounds of Formula A: (A) or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including obesity, insulin sensitivity, inflammation, cholestasis, and bile desaturation.
Public/Granted literature
- US20110003782A1 23-Substituted Bile Acids as TGR5 Modulators and Methods of Use Thereof Public/Granted day:2011-01-06
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