Invention Grant
US08410094B2 Amide compounds, their pharmaceutical compositions, their preparation method and their uses
有权
酰胺化合物，其药物组合物，其制备方法及其用途
- Patent Title: Amide compounds, their pharmaceutical compositions, their preparation method and their uses
- Patent Title (中): 酰胺化合物，其药物组合物，其制备方法及其用途
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Application No.: US13123455Application Date: 2009-09-18
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Publication No.: US08410094B2Publication Date: 2013-04-02
- Inventor: Yaqiu Long , Xing Fan , Dongzhi Feng , Li Chen , Renhai Chen
- Applicant: Yaqiu Long , Xing Fan , Dongzhi Feng , Li Chen , Renhai Chen
- Applicant Address: CN Shanghai CN Shanghai
- Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Targetdrug Co., Ltd.
- Current Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Targetdrug Co., Ltd.
- Current Assignee Address: CN Shanghai CN Shanghai
- Agency: Baker & Hostetler LLP
- Priority: CN200810200896 20081008
- International Application: PCT/CN2009/001046 WO 20090918
- International Announcement: WO2010/040272 WO 20100415
- Main IPC: C07D451/04
- IPC: C07D451/04 ; A61K31/46
Abstract:
The present invention pertains to the field of pharmaceutical chemistry and discloses 8-(3-aminopropyl)-3-exo-8-azabicyclo[3.2.1]octane-3-amino amide compounds represented by formula I, the pharmaceutical compositions, the preparation method and the use thereof. Such compounds or pharmaceutically acceptable salts thereof can be used as an antagonist of CCR5 in preparing medicaments for treating diseases mediated by CCR5, particularly HIV infection, asthma, rheumatoid arthritis, autoimmune diseases and chronic obstructive pulmonary diseases (COPD).
Public/Granted literature
- US20110251192A1 AMIDE COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS, THEIR PREPARATION METHOD AND THEIR USES Public/Granted day:2011-10-13
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