Invention Grant
US08410098B2 N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-OXO-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof
失效
-4 - 二氢-5-氧代-1,2,4-三嗪-6-基]乙基}丁酰胺的N- {1- [3-（2-乙氧基-5-（4-乙基哌嗪基）磺酰基苯基）-4,5-二氢-5-氧代-1,2,4-三嗪-6-基] 制备方法及其用途
![N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-OXO-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof](/docs/US/2013-04-02/US08410098B2/abs.jpg.600x600.jpg)
- Patent Title: N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-OXO-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof
- Patent Title (中): -4 - 二氢-5-氧代-1,2,4-三嗪-6-基]乙基}丁酰胺的N- {1- [3-（2-乙氧基-5-（4-乙基哌嗪基）磺酰基苯基）-4,5-二氢-5-氧代-1,2,4-三嗪-6-基] 制备方法及其用途
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Application No.: US12810898Application Date: 2007-12-28
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Publication No.: US08410098B2Publication Date: 2013-04-02
- Inventor: Guanghui Tian , Zheng Liu , Jin Zheng , Jingshan Shen
- Applicant: Guanghui Tian , Zheng Liu , Jin Zheng , Jingshan Shen
- Applicant Address: CN Shanghai
- Assignee: Topharman Shanghai Co., Ltd.
- Current Assignee: Topharman Shanghai Co., Ltd.
- Current Assignee Address: CN Shanghai
- Agency: Carter, DeLuca, Farrell & Schmidt LLP
- International Application: PCT/CN2007/003872 WO 20071228
- International Announcement: WO2009/082845 WO 20090709
- Main IPC: C07D253/065
- IPC: C07D253/065 ; C07D253/00 ; C07D487/04 ; A61K31/53 ; A61P15/10
![N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-OXO-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof](/abs-image/US/2013/04/02/US08410098B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III and utilized for preparing vardenafil), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure
Public/Granted literature
- US20110190495A1 N-BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF Public/Granted day:2011-08-04
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