Invention Grant
US08410103B2 (3S,11aR)-N-[2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide useful as anti-HIV agent
有权
（3S，11aR）-N- [2,4-二氟苯基）甲基] -6-羟基-3-甲基-5,7-二氧代-2,3,5,7,11,11a-六氢[1,3] 恶唑并[3,2-a]吡啶并[1,2-d]吡嗪-8-甲酰胺，用作抗HIV剂
![(3S,11aR)-N-[2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide useful as anti-HIV agent](/docs/US/2013-04-02/US08410103B2/abs.jpg.600x600.jpg)
- Patent Title: (3S,11aR)-N-[2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide useful as anti-HIV agent
- Patent Title (中): （3S，11aR）-N- [2,4-二氟苯基）甲基] -6-羟基-3-甲基-5,7-二氧代-2,3,5,7,11,11a-六氢[1,3] 恶唑并[3,2-a]吡啶并[1,2-d]吡嗪-8-甲酰胺，用作抗HIV剂
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Application No.: US13352686Application Date: 2012-01-18
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Publication No.: US08410103B2Publication Date: 2013-04-02
- Inventor: Brian Alvin Johns , Takashi Kawasuji , Teruhiko Taishi , Yoshiyuki Taoda
- Applicant: Brian Alvin Johns , Takashi Kawasuji , Teruhiko Taishi , Yoshiyuki Taoda
- Applicant Address: JP Osaka US NC Research Triangle Park
- Assignee: Shionogi & Co., Ltd.,VIIV Healthcare Company
- Current Assignee: Shionogi & Co., Ltd.,VIIV Healthcare Company
- Current Assignee Address: JP Osaka US NC Research Triangle Park
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-131161 20050428; JP2005-312076 20051027
- Main IPC: A61K31/495
- IPC: A61K31/495
![(3S,11aR)-N-[2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide useful as anti-HIV agent](/abs-image/US/2013/04/02/US08410103B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is directed to a substituted 2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2 -a]pyrido[1,2-d]pyrazine-5,7-dione useful as an anti-HIV agent, which has the formula: as well as pharmaceutically acceptable salts thereof, compostions thereof, and methods of use thereof.
Public/Granted literature
- US20120115875A1 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY Public/Granted day:2012-05-10
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