Invention Grant
US08410115B2 Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
失效
用α-4抑制化合物治疗炎症和自身免疫性疾病的方法
- Patent Title: Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds
- Patent Title (中): 用α-4抑制化合物治疗炎症和自身免疫性疾病的方法
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Application No.: US11711874Application Date: 2007-02-28
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Publication No.: US08410115B2Publication Date: 2013-04-02
- Inventor: Ivan Lieberburg
- Applicant: Ivan Lieberburg
- Applicant Address: US CA South San Francisco
- Assignee: Elan Pharmaceuticals, Inc.
- Current Assignee: Elan Pharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Main IPC: A01N43/54
- IPC: A01N43/54 ; C07D239/42 ; C07D401/04 ; A61K31/505 ; A61K31/44 ; A01N43/40
Abstract:
Alpha 4 inhibitors are used in treatment of inflammatory and autoimmune diseases, such as multiple sclerosis, Crohn's Disease, rheumatoid arthritis and asthma. Rare occurrences of progressive multifocal leucoencephalopathy during treatment with an alpha-4 agent suggest the possibility that it may be related to such treatment. Monitoring for the JC virus and educating caregivers and patients about the manifestations of progressive multifocal leucoencephalopathy can improve the safety of alpha 4 inhibitor therapy.
Public/Granted literature
- US20080044382A1 Methods of treating inflammatory and autoimmune diseases with alpha-4 inhibitory compounds Public/Granted day:2008-02-21
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