Invention Grant
US08410137B2 Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof
有权
噻吩-2-甲酰胺衍生物,其制备及其治疗用途
- Patent Title: Thiophene-2-carboxamide derivatives, preparation thereof and therapeutic use thereof
- Patent Title (中): 噻吩-2-甲酰胺衍生物,其制备及其治疗用途
-
Application No.: US13057043Application Date: 2009-07-30
-
Publication No.: US08410137B2Publication Date: 2013-04-02
- Inventor: Francis Barth , Jean-Philippe Ducoux , Patrick Gueule , Murielle Rinaldi-Carmona , Arnaud Rouquette
- Applicant: Francis Barth , Jean-Philippe Ducoux , Patrick Gueule , Murielle Rinaldi-Carmona , Arnaud Rouquette
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: FR0804384 20080801
- International Application: PCT/FR2009/051540 WO 20090730
- International Announcement: WO2010/012964 WO 20100204
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D409/06

Abstract:
The subject matter of the invention is compounds corresponding to formula (I), in which: R1 and R2, together with the nitrogen atom to which they are attached, constitute a saturated heterocyclic radical containing from 4 to 7 atoms, which is preferably substituted; one of the two substituents R3 and R6 is a group Y-A-R9; Y is an oxygen atom or an —S(O)n′—, or —OSO2 group; A is an unsubstituted (C1-C4) alkylene group; R9 is an —OR19, —CH3, —NR19R20, —CONR19R20, —NR15COR19, —S(O)nR21, or —NR13SO2R21 group; —R10 is a hydrogen atom or a (C1-C4) alkyl group. The present invention also relates to the methods of preparation and the therapeutic uses of the compounds of formula (I).
Public/Granted literature
- US20110183960A1 THIOPHENE-2-CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF Public/Granted day:2011-07-28
Information query
IPC分类: