Invention Grant
US08410147B2 Method for treating diseases associated with alterations in cellular integrity using Rho kinase inhibitor compounds
失效
使用Rho激酶抑制剂化合物治疗与细胞完整性改变相关的疾病的方法
- Patent Title: Method for treating diseases associated with alterations in cellular integrity using Rho kinase inhibitor compounds
- Patent Title (中): 使用Rho激酶抑制剂化合物治疗与细胞完整性改变相关的疾病的方法
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Application No.: US12492932Application Date: 2009-06-26
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Publication No.: US08410147B2Publication Date: 2013-04-02
- Inventor: Ward M. Peterson , John W. Lampe , Tomas Navratil , Scott D. Sorensen , Emilee H. Fulcher
- Applicant: Ward M. Peterson , John W. Lampe , Tomas Navratil , Scott D. Sorensen , Emilee H. Fulcher
- Applicant Address: US NJ Whitehouse Station
- Assignee: Inspire Pharmaceuticals, Inc.
- Current Assignee: Inspire Pharmaceuticals, Inc.
- Current Assignee Address: US NJ Whitehouse Station
- Agency: Perkins Coie LLP.
- Agent Viola T. Kung
- Main IPC: A61K31/41
- IPC: A61K31/41 ; A61K31/40 ; A61K31/405

Abstract:
This invention is directed to methods of preventing or treating diseases or conditions associated with alterations in cellular integrity including alterations in endothelial permeability, excessive cell proliferation or tissue remodeling. Particularly, this invention is directed to methods of treating diabetic nephropathy, malaria, or cancer. The method comprises identifying a subject in need of the treatment, and administering to the subject an effective amount of a novel rho kinase inhibitor compound to treat the disease.
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