Invention Grant
US08410163B2 Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors
失效
取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-腈和取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-甲酰胺作为微管蛋白聚合抑制剂
- Patent Title: Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors
- Patent Title (中): 取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-腈和取代的4-氨基-5-苯甲酰基-2-（苯基氨基）噻吩-3-甲酰胺作为微管蛋白聚合抑制剂
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Application No.: US13263489Application Date: 2010-02-09
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Publication No.: US08410163B2Publication Date: 2013-04-02
- Inventor: Paul P. Beroza , Komath V. Damodaran , Stella Lui , Wenli Ma , Zhuo Wang , Hua Xu
- Applicant: Paul P. Beroza , Komath V. Damodaran , Stella Lui , Wenli Ma , Zhuo Wang , Hua Xu
- Applicant Address: US CA Palo Alto
- Assignee: Telik, Inc.
- Current Assignee: Telik, Inc.
- Current Assignee Address: US CA Palo Alto
- Agency: Foley & Lardner LLP
- International Application: PCT/US2010/023561 WO 20100209
- International Announcement: WO2010/120400 WO 20101021
- Main IPC: A61K31/381
- IPC: A61K31/381 ; C07D409/10 ; C07D333/38
Abstract:
Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.
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