Invention Grant
- Patent Title: Antibody against calcified globule and use of the same
- Patent Title (中): 抗钙化小球的抗体及其用途
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Application No.: US13000325Application Date: 2009-03-09
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Publication No.: US08410251B2Publication Date: 2013-04-02
- Inventor: Eiji Matsuura , Hiromi Kumon , Kazuo Kojima
- Applicant: Eiji Matsuura , Hiromi Kumon , Kazuo Kojima
- Applicant Address: JP JP
- Assignee: National University Corporation Okayama University,Medical and Biological Laboratories Co., Ltd.
- Current Assignee: National University Corporation Okayama University,Medical and Biological Laboratories Co., Ltd.
- Current Assignee Address: JP JP
- Agency: Schwegman Lundberg & Woessner, P.A.
- Priority: JP2008-162566 20080620; JP2008-308016 20081202
- International Application: PCT/JP2009/054475 WO 20090309
- International Announcement: WO2009/154026 WO 20091223
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; A61K49/00
Abstract:
The present inventors carried out immunization using renal/urinary calculus-derived calcified globules or carotid artery-derived arteriosclerotic plaques, and then obtained antibodies specific to calcified globules (NLO) via screening with NLO. The present inventors demonstrated that the antibodies reacted specifically to arteriosclerotic lesions (calcified lesions) and visualized arteriosclerotic plaques (in particular, calcified lesions) by using fluorescently labeled antibodies. Accordingly, the present inventors completed the present invention.
Public/Granted literature
- US20110182817A1 ANTIBODY AGAINST CALCIFIED GLOBULE AND USE OF THE SAME Public/Granted day:2011-07-28
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