Invention Grant
- Patent Title: Process for the preparation of ziprasidone
- Patent Title (中): 齐拉西酮制备方法
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Application No.: US12921566Application Date: 2009-03-09
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Publication No.: US08410268B2Publication Date: 2013-04-02
- Inventor: Shashiprabha , Kanakamajalu Shridhara , Debkiron Mukherjee , Padmashree Badraje , K Sundarraja Rao , Kuppuswamy Nagarajan
- Applicant: Shashiprabha , Kanakamajalu Shridhara , Debkiron Mukherjee , Padmashree Badraje , K Sundarraja Rao , Kuppuswamy Nagarajan
- Applicant Address: IN Mumbai
- Assignee: Alkem Laboratories Limited
- Current Assignee: Alkem Laboratories Limited
- Current Assignee Address: IN Mumbai
- Agent George W. Moxon, II; Brian P. Harrod
- Priority: IN499/MUM/2008 20080311
- International Application: PCT/IN2009/000164 WO 20090309
- International Announcement: WO2009/116085 WO 20090924
- Main IPC: C07D417/12
- IPC: C07D417/12

Abstract:
The present invention relates to a process for preparing Ziprasidone of formula I, or a pharmaceutically acceptable salt or a solvate or a hydrate thereof; comprising the steps of reacting 1-(1,2-benzisothiazol-3-yl) piperazine of formula II or its salt: with 5-(2-haloethyl)-6-chloro-oxindole of formula III: wherein X is leaving groups like fluoro, chloro, bromo, iodo or sulphonyl; in the presence of a dispersing agent and a base in a solvent to form ziprasidone of formula I; and optionally converting the ziprasidone formed into a pharmaceutically acceptable acid addition salts of ziprasidone; or a solvate or a hydrate thereof.
Public/Granted literature
- US20110003995A1 Process for the Preparation of Ziprasidone Public/Granted day:2011-01-06
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