Invention Grant
- Patent Title: Compounds as adenosine A1 receptor antagonists
- Patent Title (中): 化合物作为腺苷A1受体拮抗剂
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Application No.: US12679941Application Date: 2008-09-30
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Publication No.: US08410282B2Publication Date: 2013-04-02
- Inventor: Lyhen Gonzalez Lio , Juan Alberto Camacho Gomez
- Applicant: Lyhen Gonzalez Lio , Juan Alberto Camacho Gomez
- Applicant Address: ES Llinars del Valles
- Assignee: Palobiofarma, S.L.
- Current Assignee: Palobiofarma, S.L.
- Current Assignee Address: ES Llinars del Valles
- Agency: Leason Ellis LLP
- Priority: ES200702643 20071002
- International Application: PCT/IB2008/002556 WO 20080930
- International Announcement: WO2009/044250 WO 20090409
- Main IPC: C07D277/00
- IPC: C07D277/00 ; C07D293/00 ; C07D413/00 ; C07D285/08 ; C07D213/55

Abstract:
This compounds correspond to the formula (I), where: R1 represents and aryl or heteroaryl group optionally substituted by one or more substituents selected from the group consisting of halogen atoms, straight or branched optionally substituted lower alkyl, cycloalkyl, hydroxy, straight or branched, optionally substituted lower alkoxy, cyano, or —CO2R′, wherein R′ represents a hydrogen atom or a straight or branched, optionally substituted lower alkyl group; R2 represents a group selected from: a) a straight or branched lower alkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms; b) a cycloalkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms; c) a straight or branched alkylcycloalkyl or cycloalkylalkyl group substituted by one or more carboxylic groups (—COOH) and optionally substituted by one or more halogen atoms. Formula (I).
Public/Granted literature
- US20100311703A1 NEW COMPOUNDS AS ADENOSINE A1 RECEPTOR ANTAGONISTS Public/Granted day:2010-12-09
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