Invention Grant
- Patent Title: Cyclic benzimidazole derivatives useful as anti-diabetic agents
- Patent Title (中): 可用作抗糖尿病药的环状苯并咪唑衍生物
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Application No.: US13124898Application Date: 2009-10-12
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Publication No.: US08410284B2Publication Date: 2013-04-02
- Inventor: Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
- Applicant: Qun Dang , Tony S. Gibson , Hongjian Jiang , De Michael Chung , Jianming Bao , Jinlong Jiang , Andy Kassick , Ahmet Kekec , Ping Lan , Huagang Lu , Gergely M. Makara , F. Anthony Romero , Iyassu Sebhat , David Wilson , Dariusz Wodka , Brett C. Bookser
- Applicant Address: US NJ Rahway US CA La Jolla
- Assignee: Merck Sharp & Dohme Corp,Metabasis Therapeutics, Inc.
- Current Assignee: Merck Sharp & Dohme Corp,Metabasis Therapeutics, Inc.
- Current Assignee Address: US NJ Rahway US CA La Jolla
- Agent Baerbel R. Brown; John C. Todaro
- International Application: PCT/US2009/060304 WO 20091012
- International Announcement: WO2010/047982 WO 20100429
- Main IPC: A61K31/675
- IPC: A61K31/675 ; C07F9/00 ; C07F9/6506
Abstract:
Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension.
Public/Granted literature
- US20110263533A1 NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS Public/Granted day:2011-10-27
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