Invention Grant
US08410312B2 Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents
有权
苯胺衍生物和苯并噻唑氟化物衍生物作为体内显像剂的氟化方法
- Patent Title: Fluorination process of anilide derivatives and benzothiazole fluorinate derivatives as in vivo imaging agents
- Patent Title (中): 苯胺衍生物和苯并噻唑氟化物衍生物作为体内显像剂的氟化方法
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Application No.: US12063470Application Date: 2006-08-11
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Publication No.: US08410312B2Publication Date: 2013-04-02
- Inventor: Anthony Eamon Storey , Clare Louise Jones , Denis Raymond Christophe Bouvet , Nicolas Lasbistes , Steven Michael Fairway , Lorenzo Williams , Alexander Mark Gibson , Robert James Nairne , Farhad Karimi , Bengt Langstrom
- Applicant: Anthony Eamon Storey , Clare Louise Jones , Denis Raymond Christophe Bouvet , Nicolas Lasbistes , Steven Michael Fairway , Lorenzo Williams , Alexander Mark Gibson , Robert James Nairne , Farhad Karimi , Bengt Langstrom
- Applicant Address: GB Buckinghamshire NO Oslo
- Assignee: GE Healthcare Limited,GE Healthcare AS
- Current Assignee: GE Healthcare Limited,GE Healthcare AS
- Current Assignee Address: GB Buckinghamshire NO Oslo
- Priority: GB0516564.2 20050812
- International Application: PCT/GB2006/003009 WO 20060811
- International Announcement: WO2007/020400 WO 20070222
- Main IPC: C07C211/46
- IPC: C07C211/46
Abstract:
The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6-14arylalkyl, —(CH2CH2O)q—CH3 wherein q is an integer of from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain novel precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed.
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