Embodiments of the present invention are generally directed to mobile inventory unit monitoring systems and methods. An exemplary embodiment of the present invention provides a mobile inventory unit monitoring system comprising a computer configured to execute at least one computer program, at least one wireless transmitter located proximate to a mobile inventory unit, a plurality of radio-frequency transceivers dispersed geographically at defined locations, and a gateway connected to a wide area network. Select information can be transmitted from the transmitter proximate to the mobile inventory unit, through a transceiver in the plurality of transceivers, through the gateway, and to the wide area network. Other aspects, features, and embodiments are also claimed and described.