A method and apparatus for a multiple lane transmission system that provides a fixed, low-latency mode of operation with reduced lane-lane skew while process, voltage, and temperature (PVT) variation, as well as other sources of variation, occur over time. Multiplexing techniques are utilized within each transmission lane to allow programmably adaptive use of phase alignment circuitry for various modes of operation. As a result, power consumption and semiconductor die area are reduced because multiple copies of phase alignment circuitry within each transmission lane are not required. Also, injection of additional jitter on the serial outputs due to continuous operation of phase alignment circuitry is prevented. Rather, multiplexers within the phase alignment circuitry selectively adapt the timing architecture to that required by the selected mode of operation.