Methods and systems herein provide for calibration of a production printing system that accommodates a plurality of different print paper types, including new paper types with no ICC profiles or optical density curves on file. One exemplary method includes printing test patches of primary colors on a first print medium, measuring colors of the test patches printed on the first print medium to determine an optical density of the first print medium, and comparing the optical density of the first print medium to a plurality of optical density curves to identify a comparable optical density curve of a different print medium. The comparable optical density curve is one of a plurality of optical density curves installed on the production printing system. The method further includes automatically selecting the comparable optical density curve to calibrate the production printing system to the different print medium for use in printing to the first print medium.