A system detects an attack on the computer system. The system identifies the attack as polymorphic, capable of modifying itself for every instance of execution of the attack. The modification of the attack is utilized to defeat detection of the attack. In one embodiment, the system determines generation of an effective signature of the attack has failed. The signature is utilized to prevent execution of the attack. The system then adjusts access to an interface to prevent further damage caused to the computer system by the attack.