According to the present disclosure an air cleaner and air filter cartridge arrangement is provided. The air filter cartridge is a removable and replaceable cartridge for use in the air cleaner. The cartridge includes, among other things, an end cap having a preferred outwardly directed radial seal and a groove. The air cleaner includes a housing with a ring projecting into an interior, positioned to project against an end of the filter cartridge, when the filter cartridge is mounted for use. Methods of assembly and installation are described.