Invention Grant
- Patent Title: Methods to increase transgene expression from bacterial-based delivery systems by co-expressing suppressors of the eukaryotic type I interferon response
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Application No.: US12964830Application Date: 2010-12-10
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Publication No.: US08414884B2Publication Date: 2013-04-09
- Inventor: Jerald C. Sadoff , Mohamad F. Jamiluddin , Ravi P. Anantha , John F. Fulkerson, Jr.
- Applicant: Jerald C. Sadoff , Mohamad F. Jamiluddin , Ravi P. Anantha , John F. Fulkerson, Jr.
- Applicant Address: US MD Bethesda
- Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee: Aeras Global TB Vaccine Foundation
- Current Assignee Address: US MD Bethesda
- Agency: Pepper Hamilton, LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K39/00 ; A01N63/00
Abstract:
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type I interferon response allows improved expression of the encoded transgene.
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