Invention Grant
US08414889B2 Protective anti-glucan antibodies with preference for β-1,3-glucans
有权
保护性抗葡聚糖抗体，优先选用β-葡聚糖
- Patent Title: Protective anti-glucan antibodies with preference for β-1,3-glucans
- Patent Title (中): 保护性抗葡聚糖抗体，优先选用β-葡聚糖
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Application No.: US13331032Application Date: 2011-12-20
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Publication No.: US08414889B2Publication Date: 2013-04-09
- Inventor: Antonio Cassone , Antonella Torosantucci
- Applicant: Antonio Cassone , Antonella Torosantucci
- Applicant Address: IT Rome IT Rome
- Assignee: Antonio Cassone,Antonella Torosantucci
- Current Assignee: Antonio Cassone,Antonella Torosantucci
- Current Assignee Address: IT Rome IT Rome
- Agency: Robins Law Group
- Agent Roberta L. Robins
- Priority: GB0420466.5 20040914
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/40
Abstract:
Anti-β-1,3-glucan antibodies have been found to be protective against systemic fungal infection with Candida albicans. The present invention provides monoclonal antibodies that bind to β-1,3-glucan, hybridoma cell lines producing the antibodies, compositions comprising the antibodies and methods of using such antibodies for treatment of microbial infections, particularly against Candida albicans and Aspergillus fumigatis infections. The antibodies of the present invention are not specific for β-1,6-glucan.
Public/Granted literature
- US20120107316A1 PROTECTIVE ANTI-GLUCAN ANTIBODIES WITH PREFERENCE FOR BETA-1,3-GLUCANS Public/Granted day:2012-05-03
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