Invention Grant
- Patent Title: Escherichia coli mutants and methods of use thereof
- Patent Title (中): 大肠杆菌突变体及其使用方法
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Application No.: US12312739Application Date: 2007-11-20
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Publication No.: US08414903B2Publication Date: 2013-04-09
- Inventor: Matthew K. Waldor , Theresa D. Ho
- Applicant: Matthew K. Waldor , Theresa D. Ho
- Applicant Address: US MA Boston
- Assignee: Tufts University
- Current Assignee: Tufts University
- Current Assignee Address: US MA Boston
- Agency: Lawson & Weitzen, LLP
- Agent Sonia K. Guterman; Teofilo Javier, Jr.
- International Application: PCT/US2007/024279 WO 20071120
- International Announcement: WO2008/133659 WO 20081106
- Main IPC: A61K39/108
- IPC: A61K39/108 ; A61K39/02 ; A01N63/00 ; C12P21/04 ; C12N15/09
Abstract:
The present invention provides methods and compositions for production of gram-negative bacterial mutants that are defective in intestinal colonization capacity and sensitive to infection by bacteriophage P1. Thus the present invention provides immunogenic compositions for the prevention or attenuation of food- and water-borne illnesses associated with ingestion of bacteria such as enterohemorrhagic Escherichia coli.
Public/Granted literature
- US20100092511A1 ESCHERICHIA COLI MUTANTS AND METHODS OF USE THEREOF Public/Granted day:2010-04-15
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