Invention Grant
- Patent Title: Methods for the generation of cartilage-like material by mechanical loading
- Patent Title (中): 通过机械加载产生软骨样材料的方法
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Application No.: US11951943Application Date: 2007-12-06
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Publication No.: US08414928B2Publication Date: 2013-04-09
- Inventor: George R. Dodge
- Applicant: George R. Dodge
- Main IPC: C12N5/00
- IPC: C12N5/00

Abstract:
A cartilage-like biomaterial is bioengineered by using a self-aggregating suspension cell culture with hydrostatic mechanical force without the use of a scaffold or foreign matrix for cell attachment during culture. The cells in suspension culture may be preconditioned prior to application of the hydrostatic mechanical force, such as hydrostatic pressure, for a period of time in the range of about 1 week to about 10 weeks. The cartilage-like biomaterial shares critical structural, phenotype, and functional characteristics with native, intact cartilage tissue.
Public/Granted literature
- US20090148876A1 METHODS FOR THE GENERATION OF CARTILAGE-LIKE MATERIAL BY MECHANICAL LOADING Public/Granted day:2009-06-11
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