Invention Grant
US08414928B2 Methods for the generation of cartilage-like material by mechanical loading 有权
通过机械加载产生软骨样材料的方法

  • Patent Title: Methods for the generation of cartilage-like material by mechanical loading
  • Patent Title (中): 通过机械加载产生软骨样材料的方法
  • Application No.: US11951943
    Application Date: 2007-12-06
  • Publication No.: US08414928B2
    Publication Date: 2013-04-09
  • Inventor: George R. Dodge
  • Applicant: George R. Dodge
  • Main IPC: C12N5/00
  • IPC: C12N5/00
Methods for the generation of cartilage-like material by mechanical loading
Abstract:
A cartilage-like biomaterial is bioengineered by using a self-aggregating suspension cell culture with hydrostatic mechanical force without the use of a scaffold or foreign matrix for cell attachment during culture. The cells in suspension culture may be preconditioned prior to application of the hydrostatic mechanical force, such as hydrostatic pressure, for a period of time in the range of about 1 week to about 10 weeks. The cartilage-like biomaterial shares critical structural, phenotype, and functional characteristics with native, intact cartilage tissue.
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