Invention Grant
US08415154B2 Compositions and methods for producing adaptive regulatory T cells
有权
用于生产适应性调节性T细胞的组合物和方法
- Patent Title: Compositions and methods for producing adaptive regulatory T cells
- Patent Title (中): 用于生产适应性调节性T细胞的组合物和方法
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Application No.: US12601682Application Date: 2008-05-29
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Publication No.: US08415154B2Publication Date: 2013-04-09
- Inventor: Randolph J. Noelle
- Applicant: Randolph J. Noelle
- Applicant Address: US NH Hanover
- Assignee: Trustees of Dartmouth College
- Current Assignee: Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- International Application: PCT/US2008/065064 WO 20080529
- International Announcement: WO2008/150853 WO 20081211
- Main IPC: C12N5/00
- IPC: C12N5/00
Abstract:
The present invention relates to a method for producing adaptive regulatory T cells from effector T cells by contacting the effector T cells with retinoic acid. Adaptive regulatory T cells produced by this method are Foxp3+, home to the gut, and are refractory to reversion in vivo. As such, such cells find application in the treatment of autoimmune disease and facilitating transplantation tolerance.
Public/Granted literature
- US20100183575A1 Compositions and Methods for Producing Adaptive Regulatory T Cells Public/Granted day:2010-07-22
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