Invention Grant
- Patent Title: Peptide mediators of cholesterol efflux
- Patent Title (中): 胆固醇流出的肽介质
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Application No.: US12999966Application Date: 2009-06-17
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Publication No.: US08415293B2Publication Date: 2013-04-09
- Inventor: John K. Bielicki , Jan Johansson
- Applicant: John K. Bielicki , Jan Johansson
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2009/047694 WO 20090617
- International Announcement: WO2009/155366 WO 20091223
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61P9/10
Abstract:
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
Public/Granted literature
- US20110190196A1 IMPROVED PEPTIDE MEDIATORS OF CHOLESTEROL EFFLUX Public/Granted day:2011-08-04
Information query
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