Invention Grant
US08415336B2 Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals
有权
环状（氮杂）中氮茚甲酰胺，它们的制备及其作为药物的用途
- Patent Title: Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals
- Patent Title (中): 环状（氮杂）中氮茚甲酰胺，它们的制备及其作为药物的用途
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Application No.: US13353889Application Date: 2012-01-19
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Publication No.: US08415336B2Publication Date: 2013-04-09
- Inventor: Henning Steinhagen , Bodo Scheiper , Hans Matter , Gary McCort , Guillaume Begis , Pascale Goberville , Berangere Thiers
- Applicant: Henning Steinhagen , Bodo Scheiper , Hans Matter , Gary McCort , Guillaume Begis , Pascale Goberville , Berangere Thiers
- Applicant Address: FR Paris
- Assignee: Sanofi
- Current Assignee: Sanofi
- Current Assignee Address: FR Paris
- Agent Ronald G. Ort
- Priority: EP09290599 20090729
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/5025 ; C07D471/04 ; C07D487/04
Abstract:
The present invention relates to cyclic indolizinecarboxamides and azaindolizinecarboxamides of the formulae Ia and Ib, wherein R, Ra, R10, R20, R30, R40, Y, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.
Public/Granted literature
- US20120232081A1 CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS Public/Granted day:2012-09-13
Information query
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