Invention Grant
US08415353B2 Amino-quinoxaline and amino-quinoline compounds for use as adenosine A2a receptor antagonists
有权
用作腺苷A2a受体拮抗剂的氨基喹喔啉和氨基 - 喹啉化合物
- Patent Title: Amino-quinoxaline and amino-quinoline compounds for use as adenosine A2a receptor antagonists
- Patent Title (中): 用作腺苷A2a受体拮抗剂的氨基喹喔啉和氨基 - 喹啉化合物
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Application No.: US12920928Application Date: 2009-03-03
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Publication No.: US08415353B2Publication Date: 2013-04-09
- Inventor: Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
- Applicant: Joel M. Harris , Bernard R. Neustadt , Hong Liu , Jinsong Hao , Andrew W. Stamford
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; Gerard M. Devlin
- International Application: PCT/US2009/035828 WO 20090303
- International Announcement: WO2009/111442 WO 20090911
- Main IPC: A61K31/495
- IPC: A61K31/495
Abstract:
Compounds of the Formula (I), where W represents CH or N; and Q represents —CN, —C(═NOH)NH2, —CONHR1 or various herein described heterocyclic radicals; as well as pharmaceutically acceptable salts, solvates, esters and prodrugs thereof are adenosine A2a receptor antagonists and, therefore, are useful in the treatment of central nervous system diseases, in particular Parkinson's disease.
Public/Granted literature
- US20110105513A1 AMINO-QUINOXALINE AND AMINO-QUINOLINE COMPOUNDS FOR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS Public/Granted day:2011-05-05
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