Invention Grant
- Patent Title: Phenylpyrrole derivative
- Patent Title (中): 苯基吡咯衍生物
-
Application No.: US13198819Application Date: 2011-08-05
-
Publication No.: US08415359B2Publication Date: 2013-04-09
- Inventor: Akihiro Furukawa , Takehiro Fukuzaki , Yukari Onishi , Hideki Kobayashi , Takeshi Honda , Yumi Matsui , Masahiro Konishi , Kenjiro Ueda , Tetsuyoshi Matsufuji
- Applicant: Akihiro Furukawa , Takehiro Fukuzaki , Yukari Onishi , Hideki Kobayashi , Takeshi Honda , Yumi Matsui , Masahiro Konishi , Kenjiro Ueda , Tetsuyoshi Matsufuji
- Applicant Address: JP
- Assignee: Daiichi Sankyo Company, Limited
- Current Assignee: Daiichi Sankyo Company, Limited
- Current Assignee Address: JP
- Agency: Dorsey and Whitney LLP
- Priority: JP2008-026519 20080206; JP2008-314479 20081210
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/4439 ; A61K31/443 ; A61K31/428 ; A61K31/427 ; A61K31/421 ; A61K31/4155 ; A61K31/4025 ; A61K31/40 ; C07D401/14 ; C07D401/12 ; C07D413/04 ; C07D413/14 ; C07D277/62 ; C07D277/20 ; C07D263/08 ; C07D263/30 ; C07D403/04 ; C07D403/14 ; C07D207/323

Abstract:
The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula —V—NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].
Public/Granted literature
- US20120022075A1 NOVEL PHENYLPYRROLE DERIVATIVE Public/Granted day:2012-01-26
Information query
IPC分类: