Invention Grant
- Patent Title: Isoxazol-3(2H)-one analogs as therapeutic agents
- Patent Title (中): 异恶唑-3(2H) - 酮类似物作为治疗剂
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Application No.: US12755010Application Date: 2010-04-06
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Publication No.: US08415378B2Publication Date: 2013-04-09
- Inventor: Jonas Boström , Leifeng Cheng , Tomas Fex , Michael Karle , Daniel Pettersen , Peter Schell
- Applicant: Jonas Boström , Leifeng Cheng , Tomas Fex , Michael Karle , Daniel Pettersen , Peter Schell
- Applicant Address: SE Sodertalje
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE Sodertalje
- Agent James Kastenmayer
- Main IPC: A01N43/40
- IPC: A01N43/40 ; A01N43/80 ; A61K31/445 ; A61K31/42 ; C07D401/00 ; C07D405/00 ; C07D409/00 ; C07D411/00 ; C07D413/00 ; C07D417/00 ; C07D419/00 ; C07D421/00 ; C07D261/00 ; C07D307/02 ; C07D315/00 ; C07D407/00

Abstract:
or a pharmaceutically suitable salt thereof, wherein, R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3, R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile, or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate; R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.
Public/Granted literature
- US20100261755A1 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS Public/Granted day:2010-10-14
Information query
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