Invention Grant
US08415384B2 Reducing myocardial reperfusion injury by the combination therapy of protein kinase A activation and B1-adrenergic receptor blockade
有权
通过蛋白激酶A激活和B1肾上腺素能受体阻断的联合治疗减少心肌再灌注损伤
- Patent Title: Reducing myocardial reperfusion injury by the combination therapy of protein kinase A activation and B1-adrenergic receptor blockade
- Patent Title (中): 通过蛋白激酶A激活和B1肾上腺素能受体阻断的联合治疗减少心肌再灌注损伤
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Application No.: US12997485Application Date: 2009-06-12
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Publication No.: US08415384B2Publication Date: 2013-04-09
- Inventor: Ming-He Huang , Kenichi Fujise , Barry F. Uretsky
- Applicant: Ming-He Huang , Kenichi Fujise , Barry F. Uretsky
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Landrum Intellectual Property
- International Application: PCT/US2009/047181 WO 20090612
- International Announcement: WO2009/152415 WO 20091217
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/675 ; A61K31/135 ; A61P9/10
Abstract:
Embodiments of the invention are directed to methods of treating reperfusion or resuscitation injury in an individual in need of such treatment, comprising the step of administering to the individual who has had, having, or is at immediate risk of having an ischemic event an amount of a composition comprising a protein kinase A (PKA) activator and a β1-adrenergic receptor antagonist sufficient to reduce reperfusion injury to an ischemic tissue.
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