Invention Grant
US08415466B2 Duplex oligonucleotides with enhanced functionality in gene regulation
有权
具有增强基因调控功能的双链寡核苷酸
- Patent Title: Duplex oligonucleotides with enhanced functionality in gene regulation
- Patent Title (中): 具有增强基因调控功能的双链寡核苷酸
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Application No.: US13460026Application Date: 2012-04-30
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Publication No.: US08415466B2Publication Date: 2013-04-09
- Inventor: Anastasia Khvorova , Devin Leake , Barbara Robertson , Annaleen Vermeulen , Christina Yamada
- Applicant: Anastasia Khvorova , Devin Leake , Barbara Robertson , Annaleen Vermeulen , Christina Yamada
- Applicant Address: US CO Lafayette
- Assignee: Dharmacon, Inc.
- Current Assignee: Dharmacon, Inc.
- Current Assignee Address: US CO Lafayette
- Agency: Dorf & Nelson LLP
- Agent Scott D. Locke, Esq.
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which contain modified nucleotides and mismatches between the two strands of the molecule at specific nucleotide positions.
Public/Granted literature
- US20120259001A1 Duplex Oligonucleotides with Enhanced Functionality in Gene Regulation Public/Granted day:2012-10-11
Information query
