Invention Grant
US08415487B2 Process for preparing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-A]pyrazine]-1′,2,3′,5(2H′)-tetraone
失效
制备(3R)-2' - (4-溴-2-氟苄基)螺 - [吡咯烷-3,4'(1'H) - 吡咯并[1,2-A]吡嗪] -1' 3',5(2H') - 四酮
- Patent Title: Process for preparing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-A]pyrazine]-1′,2,3′,5(2H′)-tetraone
- Patent Title (中): 制备(3R)-2' - (4-溴-2-氟苄基)螺 - [吡咯烷-3,4'(1'H) - 吡咯并[1,2-A]吡嗪] -1' 3',5(2H') - 四酮
-
Application No.: US13239731Application Date: 2011-09-22
-
Publication No.: US08415487B2Publication Date: 2013-04-09
- Inventor: Daisuke Tanaka , Toshiyuki Negoro
- Applicant: Daisuke Tanaka , Toshiyuki Negoro
- Applicant Address: JP Osaka
- Assignee: Dainippon Sumitomo Pharma Co., Ltd.
- Current Assignee: Dainippon Sumitomo Pharma Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2006-187588 20060707
- Main IPC: C07D207/444
- IPC: C07D207/444
![Process for preparing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-A]pyrazine]-1′,2,3′,5(2H′)-tetraone](/abs-image/US/2013/04/09/US08415487B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is a process for preparing (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2H′)-tetraone, comprising, for example, the following steps: (1) reacting a compound of the formula (III) wherein R is a C1-6 alkyl group, with 2,5-dimethoxytetrahydrofuran to provide a compound of the formula (IV) wherein R is a C1-6 alkyl group; (2) reacting the compound of the formula (IV) wherein R is a C1-6 alkyl group, with trichloroacetyl chloride to provide a compound of the formula wherein R is a C1-6 group; and (3) reacting the compound provided in step (2) with 4-bromo-2-fluorobenzylamine to provide (3R)-2′-(4-bromo-2-fluorobenzyl)spiro-[pyrrolidine-3,4′(1′H)-pyrrolo[1,2-a]pyrazine]-1′,2,3′,5(2H′)-tetraone.
Public/Granted literature
Information query