A flat panel display module having anti-shock screw-tightening structure is provided. The flat panel display module includes a display panel, a flexible printed circuit, a printed circuit board, a back plate, a fastening element, and a flexible separator. The display panel has a signal connecting end. One end of the flexible printed circuit is electrically connected to the signal connecting end while the other end is electrically connected to the printed circuit board. The printed circuit board has a through hole. The back plate accommodates the display panel. The flexible printed circuit is disposed across the back plate so that the printed circuit board is parallel to the back plate. The fastening element which has a length greater than the thickness of the printed circuit board passes through the through hole and is secured to the surface of the back plate. The flexible separator is disposed between the back plate and the printed circuit board and pushes the printed circuit board away from the back plate so that the printed circuit board touches against the fastening element. The flat panel display module maintains a space between the printed circuit board and the back plate to accomplish the purpose of anti-shock.