A method and an apparatus for preventing on-screen keys from being accidentally touched and a recording medium using the same are provided. In the present method, when a mobile device enters a communication mode, a user interface of the communication mode, which comprises at least one on-screen key, is displayed on a touch screen of the mobile device. Meanwhile, a protective mask is displayed on the touch screen to cover the on-screen key, and a function corresponding to the on-screen key covered by the protective mask is disabled. Accordingly, users can avoid accidentally touching the on-screen keys to make the mobile device perform false actions when speaking on the phone.