A bi-directional over-voltage protection circuit and a method for blocking current flow therein. The bi-directional over-voltage protection circuit comprises a regulator coupled to a lockout circuit, wherein the regulator and the lockout circuit are coupled for receiving an input signal and are coupled to a charging control circuit. A reverse path control circuit has an input coupled for receiving a control signal and an output coupled to the charging control circuit. A multi-transistor switching circuit is coupled to the forward control circuit. Preferably, the gate of each n-channel MOSFET is coupled to the charging control circuit, the drains are coupled together, and the source of one of the n-channel MOSFETS is coupled to an input and the source of the other n-channel MOSFET is coupled to an output of the bi-directional over-voltage protection circuit.