This document discloses one-time-programmable (“OTP”) memory emulation and methods of performing the same. OTP memory can be emulated by managing reads and writes to a memory array in response to an instruction to write data to a OTP memory location and selectively setting a security flag that corresponds to the memory locations. The memory array can be a NAND Flash memory array that includes multiple pages of memory. The memory array can be defined by memory blocks that can include multiple pages of memory. When an OTP write instruction is received, previously stored data can be read from a first page of memory, combined with the new data and stored to a target page of memory. A security flag can be set to prevent the target page from being reprogrammed prior to an erase.