A mattress system for a patient includes an inflatable mattress having at least one inflatable bladder, each having at least one inflation port and a plurality of selectively sealable deflation pinholes. When fully deflated the inflatable mattress may be rolled up into a compact storage configuration. An air pump is in fluid communication with the inflation port of each inflatable bladder and is adapted to pressurize the bladder with air treated with an ozone generator, sanitizer, or the like. Such an air pump is preferably controlled by a controller circuit that may be included to inflate any of the inflatable bladders and activate or deactivate the air treatment apparatus, based on, for example, a pre-programmed schedule or regiment as directed by a medical professional. Auxiliary attachments, such as an appendage sleeve, a blanket, or the like, may also be inflated with the air pump.