Invention Grant
- Patent Title: Methods for treating adult respiratory distress syndrome
- Patent Title (中): 治疗成人呼吸窘迫综合征的方法
-
Application No.: US12681058Application Date: 2008-10-01
-
Publication No.: US08420080B2Publication Date: 2013-04-16
- Inventor: Jahar Bhattacharya , Sadiqa K. Quadri , Shonit Das
- Applicant: Jahar Bhattacharya , Sadiqa K. Quadri , Shonit Das
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Evans & Molinelli PLLC
- Agent Judith A. Evans
- International Application: PCT/US2008/078483 WO 20081001
- International Announcement: WO2009/046129 WO 20090409
- Main IPC: A61K38/46
- IPC: A61K38/46

Abstract:
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter “FAKp”) strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary endothelia, and the increased barrier helps to prevent acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Thus certain embodiments of the invention are directed to prevention and treatment of ALI and ARDS by administering a therapeutically effective amount of FAKp to subjects at risk of developing or diagnosed as having either ALI or ARDS.
Public/Granted literature
- US20120027742A1 METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME Public/Granted day:2012-02-02
Information query
IPC分类: