Invention Grant
US08420122B2 Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
失效
通过控制沉淀沉淀和分离6,6-二甲基-3-氮杂 - 双环[3.1.0]己烷 - 酰胺化合物的方法和含有其的药物制剂
- Patent Title: Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
- Patent Title (中): 通过控制沉淀沉淀和分离6,6-二甲基-3-氮杂 - 双环[3.1.0]己烷 - 酰胺化合物的方法和含有其的药物制剂
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Application No.: US12080989Application Date: 2008-04-08
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Publication No.: US08420122B2Publication Date: 2013-04-16
- Inventor: Dimitrios Zarkadas , Vincenzo Liotta , Christopher Stanley Pridgen , Wing-Kee Philip Cho , Zhihui Qiu
- Applicant: Dimitrios Zarkadas , Vincenzo Liotta , Christopher Stanley Pridgen , Wing-Kee Philip Cho , Zhihui Qiu
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Julie M. Lake; Sheldon O. Heber
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K31/403 ; C07D209/52
![Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same](/abs-image/US/2013/04/16/US08420122B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a method of continuous precipitation and isolation of an amorphous solid particulate form of 3-[2-(3-tert-Butyl-ureido)-3,3-dimethyl-butyryl]-6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylic acid (2-carbamoyl-1-cyclobutylmethyl-2-oxo-ethyl)-amide having controlled physical properties. The present invention provides also pharmaceutical formulations comprising the precipitated compound.
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